abstract：:Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

journal_title：Experimental gerontology

authors： Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

更新日期：2014-10-01 00:00:00

abstract：:Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases (CVD), but the underlying mechanisms are incompletely understood. We investigated the role of mitochondrial quality control (QC, i.e., mitophagy and biogenesis) in arterial stiffening with aging. In C57BL6 mice, aging was assoc...

journal_title：Experimental gerontology

authors： LaRocca TJ,Hearon CM Jr,Henson GD,Seals DR

更新日期：2014-10-01 00:00:00

abstract：:Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...

journal_title：Experimental gerontology

authors： Cohen AA,Milot E,Li Q,Legault V,Fried LP,Ferrucci L

更新日期：2014-09-01 00:00:00

abstract：:Mechanical loading is considered to be a major parameter of the periodontal ligament (PDL) remodeling and differentiation. However, the molecular mechanisms that translate these forces to cellular responses are not fully elucidated. Especially, although aging affects PDL homeostasis, the role of cellular senescence on...

journal_title：Experimental gerontology

authors： Konstantonis D,Papadopoulou A,Makou M,Eliades T,Basdra E,Kletsas D

更新日期：2014-09-01 00:00:00

abstract：:Sex hormones are known to help maintaining the cognitive ability in male and female rats. Hypogonadism results in the reduction of the dendritic spines of central neurons which is believed to undermine memory and cognition and cause fatigue and poor concentration. In our previous studies, we have reported age-related ...

journal_title：Experimental gerontology

authors： Chen JR,Tseng GF,Wang YJ,Wang TJ

更新日期：2014-09-01 00:00:00

abstract：:Osteoporosis is extremely frequent in post-menopausal women; nevertheless, osteoporosis in men is also a severe and frequently occurring but often underestimated disease. Increasing evidence links bone loss in male idiopathic osteoporosis and age related osteoporosis to osteoblast dysfunction rather than increased ost...

journal_title：Experimental gerontology

authors： Föger-Samwald U,Patsch JM,Schamall D,Alaghebandan A,Deutschmann J,Salem S,Mousavi M,Pietschmann P

更新日期：2014-09-01 00:00:00

abstract：:Over the last 40 years it has become clear that telomeres, the end of the chromosomes, and the enzyme telomerase reverse transcriptase (TERT), which is required to counteract their shortening, play a pivotal role in senescence and aging. However, over the last years several studies demonstrated that TERT belongs to th...

journal_title：Experimental gerontology

authors： Ale-Agha N,Dyballa-Rukes N,Jakob S,Altschmied J,Haendeler J

更新日期：2014-08-01 00:00:00

abstract：:Culturing Caenorhabditis elegans in axenic medium leads to a twofold increase in lifespan and considering the similar phenotypical traits with dietary restricted animals, it is referred to as axenic dietary restriction (ADR). The free radical theory of aging has suggested a pivotal role for mitochondria in the aging p...

journal_title：Experimental gerontology

authors： Castelein N,Muschol M,Dhondt I,Cai H,De Vos WH,Dencher NA,Braeckman BP

更新日期：2014-08-01 00:00:00

abstract：:Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...

journal_title：Experimental gerontology

authors： Maglioni S,Schiavi A,Runci A,Shaik A,Ventura N

更新日期：2014-08-01 00:00:00

abstract：:Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...

journal_title：Experimental gerontology

authors： Dantas AP,Onetti Y,Oliveira MA,Carvalho MH,Heras M,Vila E,Jiménez-Altayó F

更新日期：2014-07-01 00:00:00

abstract：:The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...

journal_title：Experimental gerontology

authors： Iohara K,Murakami M,Nakata K,Nakashima M

更新日期：2014-04-01 00:00:00

abstract：:The TOR kinase pathway is central in modulating aging in a variety of animal models. The target of rapamycin (TOR) integrates a complex network of signals from growth conditions, nutrient availability, energy status, and physiological stresses and matches an organism's growth rate to the resource environment. Importan...

journal_title：Experimental gerontology

authors： Snell TW,Johnston RK,Rabeneck B,Zipperer C,Teat S

更新日期：2014-04-01 00:00:00

abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....

journal_title：Experimental gerontology

authors： Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

更新日期：2014-04-01 00:00:00

abstract：:SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...

journal_title：Experimental gerontology

authors： Xiong H,Dai M,Ou Y,Pang J,Yang H,Huang Q,Chen S,Zhang Z,Xu Y,Cai Y,Liang M,Zhang X,Lai L,Zheng Y

更新日期：2014-03-01 00:00:00

abstract：:Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matc...

journal_title：Experimental gerontology

authors： de Goeij MC,Halbesma N,Dekker FW,Wijsman CA,van Heemst D,Maier AB,Mooijaart SP,Slagboom PE,Westendorp RG,de Craen AJ

更新日期：2014-03-01 00:00:00

abstract：:Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...

journal_title：Experimental gerontology

authors： Russ DW,Wills AM,Boyd IM,Krause J

更新日期：2014-02-01 00:00:00

abstract：:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...

journal_title：Experimental gerontology

authors： Taghli-Lamallem O,Jagla K,Chamberlain JS,Bodmer R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Aging has been reported to be associated with changes in immune function. Although frequent infection and the development of malignancy suggest the decline of immune function with aging, changes toward proinflammatory conditions also develop at the same time. Th17 cells are well known CD4(+) T cell subpopulat...

journal_title：Experimental gerontology

authors： Lim MA,Lee J,Park JS,Jhun JY,Moon YM,Cho ML,Kim HY

更新日期：2014-01-01 00:00:00

abstract：:Temporal discounting occurs when a greater delayed reward is forsaken for a smaller immediate reward, and has been associated with a number of financial and health care outcomes important for older adults. Using resting-state fMRI and seed regions of interest in the left and right fronto-insular (FI) cortices, we expl...

journal_title：Experimental gerontology

authors： Han SD,Boyle PA,Yu L,Fleischman DA,Arfanakis K,Bennett DA

更新日期：2013-12-01 00:00:00

abstract：:The present study investigated the time-course for aging-associated effects on contractile and relaxing vascular responses and nitric oxide (NO) production in the aorta from female senescence-accelerated resistant (SAMR1) and prone (SAMP8) mice. Both SAMR1 and SAMP8 were studied at three different ages: 3 (young), 6 (...

journal_title：Experimental gerontology

authors： Novella S,Dantas AP,Segarra G,Vidal-Gómez X,Mompeón A,Garabito M,Hermenegildo C,Medina P

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND/AIM:Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade in...

journal_title：Experimental gerontology

authors： Olesen J,Ringholm S,Nielsen MM,Brandt CT,Pedersen JT,Halling JF,Goodyear LJ,Pilegaard H

更新日期：2013-11-01 00:00:00

abstract：:Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...

journal_title：Experimental gerontology

authors： Cueno ME,Tamura M,Imai K,Ochiai K

更新日期：2013-11-01 00:00:00

abstract：:The aim of this study was to compare voluntary and involuntary force generating capacity of the triceps surae muscles in healthy young and older adult participants during isometric and isokinetic contractions. Ultrasound was used to measure medial gastrocnemius (MG) fascicle length during maximal voluntary isometric c...

journal_title：Experimental gerontology

authors： Barber LA,Barrett RS,Gillett JG,Cresswell AG,Lichtwark GA

更新日期：2013-11-01 00:00:00

abstract：:Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...

journal_title：Experimental gerontology

authors： Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

更新日期：2013-10-01 00:00:00

abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...

journal_title：Experimental gerontology

authors： Kaya RD,Nakazawa M,Hoffman RL,Clark BC

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection...

journal_title：Experimental gerontology

authors： Kwan J,Horsfield G,Bryant T,Gawne-Cain M,Durward G,Byrne CD,Englyst NA

更新日期：2013-09-01 00:00:00

abstract：:Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR block...

journal_title：Experimental gerontology

authors： Hwang MH,Yoo JK,Luttrell M,Kim HK,Meade TH,English M,Nichols WW,Christou DD

更新日期：2013-08-01 00:00:00

abstract：:It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...

journal_title：Experimental gerontology

authors： Starnes JW,Neidre DB,Nyman JS,Roy A,Nelson MJ,Gutierrez G,Wang X

更新日期：2013-08-01 00:00:00

abstract：:In the central nervous system, the degree of decline in memory retrieval along the aging process depends on the quantity and quality of the stimuli received during lifetime. The cholinergic system modulates long-term potentiation and, therefore, memory processing. This study evaluated the spatial memory, the synaptic ...

journal_title：Experimental gerontology

authors： Baraldi T,Schöwe NM,Balthazar J,Monteiro-Silva KC,Albuquerque MS,Buck HS,Viel TA

更新日期：2013-08-01 00:00:00

abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...

journal_title：Experimental gerontology

authors： Brown-Borg HM,Borg KE

更新日期：2013-07-01 00:00:00

abstract：:DNA methylation patterns change as individuals grow older, and DNA methylation appears susceptible to modification by the diet. Thus DNA methylation may be a mechanism through which diet can affect aging and longevity. We propose that effects on DNA methylation also contribute to the extension in lifespan observed in ...

journal_title：Experimental gerontology

authors： Ford D

更新日期：2013-07-01 00:00:00

abstract：:Aging is associated with altered immune responses, particularly with a diminished CD8 T cell response. Although both intrinsic and extrinsic factors are hypothesized to impact this decreased T cell response, the direct evidence of an intrinsic deficiency in virus-specific CD8 T cells is limited. In this study, a TCR t...

journal_title：Experimental gerontology

authors： Jiang J,Fisher EM,Murasko DM

更新日期：2013-06-01 00:00:00

abstract：:We previously reported that lysophosphatidylcholine (LPC) is a mediator of endothelial dysfunction in the expression of adhesion molecules (AMs) during aging. This study aimed at investigating the effects of betaine on LPC-related expression of AMs and the molecular modulation of nuclear factor-κB (NF-κB) activation i...

journal_title：Experimental gerontology

authors： Lee EK,Jang EJ,Jung KJ,Kim DH,Yu BP,Chung HY

更新日期：2013-05-01 00:00:00

abstract：:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younge...

journal_title：Experimental gerontology

authors： Skjærvø GR,Røskaft E

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. METH...

journal_title：Experimental gerontology

authors： Tomaschitz A,Pilz S,Pieske B,Ritz E,März W,Meinitzer A,Dobnig H,Amrein K,Kienreich K,Verheyen N,Kraigher-Krainer E,Drechsler C,Colantonio C,Wagner D,Fahrleitner-Pammer A

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...

journal_title：Experimental gerontology

authors： Shavit L,Lifschitz M,Slotki I,Oren A,Tauber R,Bitran D,Fink D

更新日期：2013-03-01 00:00:00

abstract：:Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen S...

journal_title：Experimental gerontology

authors： Savela S,Saijonmaa O,Strandberg TE,Koistinen P,Strandberg AY,Tilvis RS,Pitkälä KH,Miettinen TA,Fyhrquist F

更新日期：2013-01-01 00:00:00

abstract：:The field of toxicology adopted the threshold dose response in the early decades of the 20th century. The model was rapidly incorporated into governmental regulatory assessment procedures and became a central feature of chemical evaluation and assessment. The toxicological community never validated the capacity of thi...

journal_title：Experimental gerontology

authors： Calabrese EJ

更新日期：2013-01-01 00:00:00

abstract：:Numerous trials have shown that physical activity and exercise training have beneficial effects in general older populations. However, few have studied its effectiveness among people with dementia. The aim of this systematic review is to examine the efficacy of trials using a rigorous randomised, controlled design and...

journal_title：Experimental gerontology

authors： Pitkälä K,Savikko N,Poysti M,Strandberg T,Laakkonen ML

更新日期：2013-01-01 00:00:00

abstract：:Aging in a given individual can be characterized by the number of deficits (symptoms, signs, laboratory abnormalities, disabilities) that they accumulate. The number of accumulated deficits, more than their nature, well characterizes health status in individuals - the proportion of deficits present in an individual to...

journal_title：Experimental gerontology

authors： Mitnitski A,Song X,Rockwood K

更新日期：2012-12-01 00:00:00